Retinoblastoma Tumor Suppressor Gene: An Overview
نویسندگان
چکیده
منابع مشابه
Conditional haploinsufficiency of the retinoblastoma tumor suppressor gene
Recent work demonstrates that retention of a single functional retinoblastoma susceptibility (RB1) allele is insufficient to maintain genome stability. Haploinsufficiency of RB1 accelerates cancer pathogenesis in concert with inactivation of tumor protein p53. Collectively, multiple lines of evidence suggest revision of the '2-hit' model to include conditional haploinsufficiency of RB1.
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ژورنال
عنوان ژورنال: Journal of Indian Academy of Oral Medicine and Radiology
سال: 2012
ISSN: 0975-1572
DOI: 10.5005/jp-journals-10011-1255